Electron Transfer Activation of Chromopyrrolic Acid by Cytochrome P450 En Route to the Formation of an Antitumor Indolocarbazole Derivative: Theory Supports Experiment

摘要

P450 StaP (CYP245A1) belongs to the family of cytochromes P450 and catalyzes the formation of staurosporine from chromopyrrolic acid (CPA, 1 in Scheme 1). There is a recent surge of interest in this enzyme because of the anticancer activity of staurospori