Effects of Trimethylamine /V-Oxide (TMAO) and Crowding Agents on the Stability of RNA Hairpins

摘要

We study the effect of the osmolyte, Trimethylamine N-Oxide (TMAO), which accumulates in cells in response to osmotic stress, on the stability of RNA hairpins. All atom molecular dynamics (MD) simulations of a nucleotide and the 22-nucleotide RNA hairpin