Structural and Dynamical Characterization of Fibrils from a Disease-Associated Alanine Expansion Domain Using Proteolysis and Solid-State NMR Spectroscopy

摘要

Codon expansions in the gene for the human nuclear poly(A) binding protein PABPN1 result in the extension of a natural oligoala-nine stretch of 10 residues positioned directly after the start methionine to a maximum of 17 alanines. Individuals possessing