Expanding the Realm of Ultrafast Protein Folding: gpW, a Midsize Natural Single-Domain with α+β Topology that Folds Downhill

摘要

All ultrafast folding proteins known to date are either very small in size (less than 45 residues), have an a-helix bundle topology, or have been artificially engineered. In fact, many of them share two or even all three features. Here we show that gpW, a