Generation of Thiocillin Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus

摘要

The thiazolyl peptide antibiotics constitute a family of >80 members with the common characteristics of a central pyridine/ piperidine ring typically decorated by three thiazole substituents and a macrocyclic peptide ring containing additional thiazoles (Figure 1). Some members of this antibiotic group, such as thiostrepton and nosiheptide, have a second macrocyclic ring. The thiazolyl peptide natural products target one of two sequential steps in bacterial protein synthesis.