Total Synthesis of (+)-Sorangicin A

摘要

Myxobacteria Sorangium cellulosum is a rich source of secondary metabolites possessing important biological profiles. Perhaps most notable, the epothilone class of natural products, analogues of which are currently in clinical use for the treatment of solid tumors resistant to alternative treatments (i.e., Taxol), were isolated by Hoefle and co-workers in 1996 from the S. cellulosum strain So ce 90. Earlier (1985), the same research group reported the isolation of members of another family of architecturally complex macrolides from the strain So ce 12, termed the sorangicins.