Marinopyrrole A Target Elucidation by Acyl Dye Transfer

摘要

While a variety of methods exist, target identification continues to pose a fundamental challenge in elucidating a natural product's mode of action. The development of solutions to this problem is essential to advancing drugs into the discovery pipeline. The complex structural diversity that characterizes natural products complicates the adoption of routine protocols for these studies. A systematic approach to target elucidation would both facilitate the introduction of drugs into clinical trials and challenge leads early on should undesired targets be identified.