Total Synthesis and Structural Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal β-N-Acetylglucosaminidases

摘要

TMG-chitotriomycin (1) was recently disclosed by Kanzaki and co-workers from the culture filtrate of Streptomyces anulatus NBRC13369, which exhibited potent and selective inhibition against the β-N-acetylglucosaminidase (GlcNAcase) of insects and fungi but no activity against the enzyme of humans and plants. This unique inhibitory spectrum could lead to new insights for understanding the molecular mechanisms of the important chitin-degrading systems occurring in a wide variety of organisms and the development of new antifungal and insecticidal agents.