Spotlights on Recent JACS Publications

摘要

A molecular machine-the bc_1 protein complex-helps generate the fuel of life, ATP, but at the same time is suspected of producing a superoxide, a reactive and mobile radical that is toxic and may accelerate aging. The bc_1 protein complex pumps protons across the mitochondrial membrane using a series of redox reactions, moving electrons from quinol substrates to downstream proteins. An intermediate radical is created at each step, offering multiple opportunities for stray reactions to make a superoxide. However, because of the experimental challenges in detecting oxygen species, researchers are not sure where or how the protein complex produces a superoxide.