Extended X-ray Absorption Fine Structure Analysis of Coenzyme B_12 Bound to Methylmalonyl-Coenzyme A Mutase Using Global Mapping Techniques

摘要

Thus, the change in coordination of the nitrogenous acial ligand engineered by the enzyme does not significantly contribute to a trans effect in the ground state. Weakening of the Co-C bond must be initiated by substrate binding. In addition, the global mapping technique resolves discrepancies between previous EXAFS results and crystallographic data on aquocobalamin.