目的 研究单次静脉给予右旋雷贝拉唑钠对Beagle犬产生的毒性,并与雷贝拉唑钠进行比较.方法 采用近似致死量试验法进行Beagle犬单次给药毒性试验,动物分组后以不同的剂量给药1次,药后观察动物反应,检测体重、死亡率、血液学、血液生化学指标,连续观察14 d后剖检,观察主要脏器的病变.结果 Beagle犬单次给予右旋雷贝拉唑钠和雷贝拉唑钠的近似致死量范围分别为192.2~288.3 mg·kg-1和128.1~192.2 mg·kg-1,死亡Beagle犬急性毒性主要表现为流涎、呕吐、四肢无力、震颤、呼吸急促、俯卧不动、抽搐、躯体强直继而死亡.结论 右旋雷贝拉唑钠对Beagle犬的单次给药毒性反应与雷贝拉唑钠基本一致,但毒性较雷贝拉唑钠小.%Objective To study the single-dose toxicity of dexrabeprazole sodium in Beagle dogs and compare the toxicity of dexrabeprazole sodium with rabeprazole sodium. Methods Approximate lethal dose methods were adopted to evaluate the single-dose toxicity of dexrabeprazole sodium in Beagle dogs. Animals were divided into different groups and were administered with different dose for one time. The general symptoms were observed and body weight, hematology, blood biochemistry and histopathology were detected after administration. The animals were autopsied and lesion of main organs were observed after continuous observation for 14 days. Results The approximate lethal doses of dexrabeprazole sodium and rabeprazole sodium in Beagle dog are 192.2~288.3 mg·kg -1 and 128.1~192.2 mg·kg -1 respectively. The main acute toxicity symptoms of dead dogs are salivation, vomiting, weakness of limbs, tremble, tachypnea, prone position, convulsion, somatic rigidity, and eventually to death. Conclusion The toxic reactions of dexrabeprazole sodium in Beagle dogs are similar to that of rabeprazole sodium, but the toxicity level is higher than that of rabeprazole sodium .
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